Izityalo zamayeza esintu zixatyiswe ukutyhubela iminyaka ukuze zibonelele ngoluhlu lwezifo.Nangona kunjalo ukwahlula iimolekyuli ezithile ezisebenzayo kudidi lwemixube ebumba uninzi lwezityalo kunokuba ngumsebenzi onzima.Ngoku, abaphandi kwiYunivesithi yaseToyama, eJapan baye baphuhlisa indlela yokwahlula kunye nokuchonga iikhompawundi ezisebenzayo kumayeza ezityalo.
Idatha entsha-epapashwe kutshanje kwiFrontiers in Pharmacology kwinqaku elinesihloko esithi, "Isicwangciso esicwangcisiweyo sokufumanisa iChiza loNyango lweSifo se-Alzheimer kunye neMolekyuli ekuJoliswe kuyo.“, bonisa ukuba indlela entsha ichonga iikhompawundi ezininzi ezisebenzayo ezivela kwi-Drynaria rhizome, iyeza lezityalo zesintu, eliphucula inkumbulo kunye nokunciphisa iimpawu zesifo kwimodeli yempuku yesifo i-Alzheimer.
Ngokwesiqhelo, izazinzulu ziya kuphinda zivavanye amayeza ezityalo ezikrwada kwiimvavanyo zaselebhu ukubona ukuba kukho naziphi na iikhompawundi ezibonisa ifuthe kwiiseli ezikhule kwi-vitro.Ukuba ikhompawundi ibonisa isiphumo esilungileyo kwiiseli okanye kwiityhubhu zovavanyo, inokusetyenziswa njengechiza, kwaye izazinzulu ziyaqhubeka ukuyivavanya kwizilwanyana.Nangona kunjalo, le nkqubo inzima kwaye ayithethi ngeenguqu ezinokuthi zenzeke kumachiza xa engena emzimbeni-ii-enzymes ezisegazini nasesibindini zinokusebenzisa iziyobisi kwiintlobo ezahlukeneyo ezibizwa ngokuba yi-metabolites.Ukongezelela, ezinye iindawo zomzimba, ezifana nengqondo, kunzima ukufikelela kumachiza amaninzi, kwaye kuphela iziyobisi ezithile okanye i-metabolites yazo ziya kungena kwezi zicubu.
"Iikhompawundi zomgqatswa ezichongiweyo kwizikrini zamachiza esiqhelo amayeza ezityalo azisoloko zizikhompawundi eziyinyani ezisebenzayo kuba ezi mvavanyo zityeshela i-biometabolism kunye nokuhanjiswa kwezicubu," ucacisile umphandi wophononongo oluphezulu uChihiro Tohda, Ph.D., unjingalwazi onxulumene ne-neuropharmacology kwiYunivesithi yaseToyama. ."Ke, sijonge ukuphuhlisa iindlela ezisebenzayo zokuchonga iikhompawundi ezisebenzayo ezithathela ingqalelo ezi zinto."
Kuphononongo, iqela le-Toyama lisebenzise iigundane ezinokuguqulwa kofuzo njengomzekelo wesifo se-Alzheimer.Olu tshintsho lunika iimpuku iimpawu ezithile zesifo sika-Alzheimer, kubandakanywa inkumbulo encitshisiweyo kunye nokwakhiwa kweeprotheyini ezithile engqondweni, ezibizwa ngokuba yi-amyloid kunye ne-tau protein.
"Sichaza isicwangciso esicwangcisiweyo sokuvavanya abaviwa be-bioactive kumayeza endalo asetyenziselwa isifo se-Alzheimer's (AD)," ababhali babhala.“Sifumanise ukuba i-Drynaria rhizome inokuphucula ukusebenza kwenkumbulo kwaye iphucule i-AD pathologies kwiimpuku ze-5XFAD.Uhlalutyo lwe-biochemical lukhokelela ekuchongeni i-metabolites ye-bioeffective ethunyelwa kwingqondo, oko kukuthi, i-naringenin kunye ne-glucuronides yayo.Ukuphonononga indlela yokwenza isenzo, sidibanise ukuzinza okuhambelana neziyobisi kunye ne-immunoprecipitation-liquid chromatography / mass spectrometry uhlalutyo, ukuchonga iprotheni ye-collapsin yomlamli weprotheni 2 (CRMP2) njengethagethi ye-naringenin. "
Izazinzulu zafumanisa ukuba isityalo esisicatshulwa sinciphise ukukhubazeka kwememori kunye namanqanaba e-amyloid kunye neeprotheni ze-tau kwiingqondo zempuku.Ngaphaya koko, iqela emva koko lavavanya izicubu zobuchopho bempuku kwiiyure ezintlanu emva kokuba linyanga iimpuku ngesicatshulwa.Bafumanisa ukuba imichiza emithathu yesi sityalo iye yangena ebuchotsheni—inaringenin kunye neenaringenin metabolites ezimbini.
Xa abaphandi baphatha iigundane nge-naringenin ecocekileyo, baqaphela ukuphuculwa okufanayo kwintsilelo yememori kunye nokunciphisa kwiiprotheni ze-amyloid kunye ne-tau, oku kuthetha ukuba i-naringenin kunye ne-metabolites yayo mhlawumbi i-compounds esebenzayo ngaphakathi kwesityalo.Bafumene iprotheni ebizwa ngokuba yi-CRMP2 ethi i-naringenin ibophelela kwii-neuron, ezibangela ukuba zikhule, zicebisa ukuba oku kunokuba yindlela apho i-naringenin inokuphucula iimpawu ze-Alzheimer's disease.
Abaphandi banethemba lokuba obu buchule butsha bunokusetyenziswa ukuchonga olunye unyango."Sisebenzisa le ndlela ukuze sifumane amayeza amatsha kwezinye izifo ezinjengokulimala komnqonqo, ukudandatheka, kunye ne-sarcopenia," uGqr. Tohda waphawula.
Ixesha lokuposa: Mar-23-2022